منابع مشابه
Toxicity and lifespan extension
The RB pathway is one of the best-studied and most frequently altered pathways leading to loss of proliferative control in cancer. it can be disrupted by a variety of means including, but not limited to, epigenetic silencing, allelic loss or mutation of RB1. in some cancers including breast cancer, amplification of the CCND1 gene or overexpression of cyclin D1 is commonly observed.1 in others, ...
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, © Mangan This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. AMPK is a highly evolutionarily conserved energy sensor. By evolutionarily conserved is meant that essentially all living organisms, includi...
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A number of small molecules with the ability to extend the lifespan of multiple organisms have recently been discovered. Resveratrol, amongst the most prominent of these, has gained widespread attention due to its ability to extend the lifespan of yeast, worms, and flies, and its ability to protect against age-related diseases such as cancer, Alzheimer's, and diabetes in mammals. In this review...
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BACKGROUND Chronological aging of yeast cells is commonly used as a model for aging of human post-mitotic cells. The yeast Saccharomyces cerevisiae grown on glucose in the presence of ammonium sulphate is mainly used in yeast aging research. We have analyzed chronological aging of the yeast Hansenula polymorpha grown at conditions that require primary peroxisome metabolism for growth. METHODO...
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ژورنال
عنوان ژورنال: Nature
سال: 1999
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35011555